Akci�er Kanserinin ve Kemoterapinin Uyku ve Ya�am Kalitesi �zerine Etkisi

K�z�l�rmak, Deniz; G�ktalay, Tu�ba; G�ltekin, �kke�; Havlucu, Yavuz; �elik, P�nar

Cilt : 37 Say� : 3 Y�l : 2023

37/3Son Say� Erken Bask� Ar�iv Pop�ler Makaleler

Yazar Katk� Formu

Akci�er Kanserinin ve Kemoterapinin Uyku ve Ya�am Kalitesi �zerine Etkisi [G��s Hastanesi Dergisi]

G��s Hastanesi Dergisi. 2021; 35(2): 82-90 | DOI: 10.5222/IGH.2021.55265

Akci�er Kanserinin ve Kemoterapinin Uyku ve Ya�am Kalitesi �zerine Etkisi

Deniz K�z�l�rmak, Tu�ba G�ktalay, �kke� G�ltekin, Yavuz Havlucu, P�nar �elik
Manisa Celal Bayar �niversitesi, T�p Fak�ltesi, G��s Hastal�klar� Anabilim Dal�

Ama�: Akci�er kanseri, hem lokal hem de sistemik etkilerine ba�l� olarak uyku ve ya�am kalitelerini etkilemektedir. Akci�er kanseri tedavisinde s�kl�kla kullan�lan kemoterapi ise; hastal�k yan�t�, kemoterapi yan etkileri, kemoterap�tik ajana ba�l� sistemik etkiler ve imm�nsupresyon sonucu geli�en komplikasyonlar nedenleriyle uyku ve ya�am kalitelerini etkileyebilmektedir. Bu �al��mada, lokal ileri ve metastatik evre akci�er kanserli hastalarda, kemoterapinin erken d�nemde uyku ve ya�am kaliteleri �zerine etkisi ara�t�r�ld�.
Y�ntem: Lokal ileri ve metastatik evre akci�er kanseri tan�s� ile tek ba��na kemoterapi alan hastalara tan� an�nda ve 3. k�r kemoterapi sonras� uyku kalitesi ve ya�am kalitesini de�erlendirebilmek i�in Pittsburg Uyku Kalitesi �ndeksi ve EORTC QLQ-C30 Kanser Hastalar�n�n Ya�am Kalitesi �l�e�i uyguland�. Hastalar�n ortalama ya�� 61.85�ti (�6.80) ve %89.8�i erkekti. Tan� an�nda hastalar�n %69,5�i k�t� uyku kalitesine sahipti. Fonksiyonel parametreler a��s�ndan en �ok fiziksel i�lev etkilenmi� olarak saptand�. Ya�am kalitesini en �ok etkileyen semptomlar h�lsizlik ve dispneydi.
Bulgular: Akci�er kanserli hastalarda tan� s�ras�nda uyku ve ya�am kaliteleri aras�nda belirgin korelasyon g�zlendi, ancak kemoterapi sonras� erken d�nemde uyku kalitesinde anlaml� de�i�iklik saptanmad�. Ya�am kalitesi skorlar� de�erlendirildi�inde kemoterapi sonras� sosyal i�levlerde ve bulant� semptomunda istatistiksel olarak zay�f; h�lsizlik semptomunda istatistiksel olarak belirgin k�t�le�me vard�. Di�er ya�am kalitesi parametreleri genel olarak tedavi �ncesi ile benzerdi.
Sonu�: Sonu� olarak, akci�er kanserli hastalarda kemoterapi erken d�nemde hastalar�n uyku kalitesinde belirgin bir de�i�iklik yapm�yorken ya�am kalitesini olumsuz y�nde etkileyebilmektedir.

Anahtar Kelimeler: uyku kalitesi, ya�am kalitesi, akci�er kanseri, kemoterapi

The Effect of Lung Cancer and Chemotherapy on Sleep Quality and Quality of Life

Deniz K�z�l�rmak, Tu�ba G�ktalay, �kke� G�ltekin, Yavuz Havlucu, P�nar �elik
Manisa Celal Bayar University, Faculty of Medicine, Pulmonary Diseases Department

Objective: Lung cancer affects the quality of sleep and life depending on both local and systemic impacts. Chemotherapy that is frequently used in the treatment of lung cancer can affect quality of sleep and life due to disease response, side effects of chemotherapy, systemic effects due to chemotherapeutic agents and complications of immunosuppression. The sleep and life quality levels of patients with locally advanced and metastatic stage lung cancer and the effect of chemotherapy on sleep and quality of life in this patient group were investigated in this study.
Method: The Pittsburg Sleep Quality Index and the EORTC QLQ-C30 Cancer Patients� Quality of Life Scale were applied to the patients who received chemotherapy alone with diagnosis of locally advanced and metastatic stage lung cancer at the time of diagnosis and after the third course of chemotherapy to evaluate sleep quality and quality of life. The mean age of the patients was 61.85 (� 6.80) and 89.8% of them were male. 69.5% of all patients had poor sleep quality at the time of diagnosis. Physical function was found to be affected the most in terms of functional parameters. The symptoms that most affected the quality of life were fatigue and dyspnea.
Results: A significant correlation was observed between sleep quality and quality of life at the time of diagnosis in patients with lung cancer, but no significant change was found in sleep quality in the early period after chemotherapy. There was a statistically weak worsening in social functions and nausea symptom after chemotherapy and a statistically significant worsening in the malaise symptom when the quality of life scores were evaluated. Other quality of life parameters were generally similar to those before treatment.
Conclusion: In conclusion, while chemotherapy does not make a significant change in the sleep quality of patients in the early period in patients with lung cancer, it may negatively affect the quality of life.

Keywords: sleep quality, quality of life, lung cancer, chemotherapy

Sorumlu Yazar: Deniz K�z�l�rmak, T�rkiye
Makale Dili: T�rk�e

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