Göðüs Hastanesi Dergisi. 2023; 37(2): 94-99 | DOI: 10.14744/IGH.2023.83584

COVID-19 Hastalarý Ýçin Prognostik Faktörler ve Eozinofillerin Rolü

Nuran Katgý, Pýnar Çimen, Çaðrý Atasoy
Saðlýk Bilimleri Üniversitesi, Dr. Suat Seren Göðüs Hastalýklarý ve Cerrahisi Eðitim ve Araþtýrma Hastanesi, Göðüs Hastalýklarý Kliniði, Ýzmir, Türkiye

Amaç: Çalýþmamýzda koronavirüs hastalýðý (COVID-19) olan hastalarda kan eozinofil düzeyinin hastalýk þiddeti ile iliþkisi ve prognoza etkisinin araþtýrýlmasý amaçlanmaktadýr.
Gereç ve Yöntemler: Çalýþmaya, 11 Mart 2020-15 Mayýs 2020 tarihleri arasýnda hastanemizde klinikte yatmýþ olan ve ayaktan baþvuran gerçek zamanlý polimeraz zincir reaksiyonu (PCR) ile tanýsý doðrulanmýþ 434 COVID-19 hastasý dahil edildi.
Bulgular: Lenfosit sayýsý, eozinofil sayýsý ve yüzdesinin mortal grupta anlamlý þekilde düþük olduðu görüldü (sýrasýyla p=0,004, p=0,043, p<0,001). Kan C-reaktif protein (CRP) deðeri de mortal grupta yüksek saptandý (p<0,001). Radyolojik bulgulara bakýldýðýnda plevral efüzyonun eþlik ettiði tablolarýn daha mortal seyrettiði görüldü (p<0,001). Ayrýca mortal seyreden hastalarda anlamlý þekilde daha fazla lob tutulumu (ortalama 4,5) gözlendi (p=0,009). Çok deðiþkenli lojistik regresyon analizi sonuçlarýna göre 50-64 yaþ aralýðý (p=0,028), nefes darlýðý (p=0,011), bulantý kusma (p=0,007) þikayetlerinin olmasý, kan tablosunda eozinofil sayý ve yüzdesindeki düþüklük (p=0,001) ve radyolojik bulgularda plevral efüzyonun (p=0,026) eþlik ettiði durumlar mortalite için önemli risk faktörleri olarak belirlendi.
Sonuç: COVID-19 hastalarýnda baþlangýçta lenfopeni ile birlikte eozinopeni ve CRP yüksekliðinin eþlik etmesi kötü prognoz göstergesi olup, mortalite ile iliþkili bulundu.

Anahtar Kelimeler: COVID-19, eozinopeni, mortalite, pnömoni, prognoz.

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Prognostic Factors for COVID-19 Patients and Role of Eosinophils

Nuran Katgý, Pýnar Çimen, Çaðrý Atasoy
Department of Pulmonology, University of Health Sciences, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Ýzmir, Türkiye

Objective: We planned to investigate the relationship of blood eosinophil level with disease severity and its effect on prognosis in coronavirus disease 2019 (COVID-19) patients.
Material and Methods: Four hundred and thirty-four COVID-19 patients who were hospitalized in the ward and admitted to our hospital between March 11, 2020, and May 15, 2020, and whose diagnosis was confirmed by real-time-polimerase chain reaction were included in the study.
Results: Lymphocyte, eosinophil count, and percentage were found to be significantly lower in mortal group (p=0.004, p=0.043, p<0.001, respectively). The blood c-reactive protein (CRP) value was also found to be high in mortal group (p<0.001). When the radiological findings accompanied by pleural effusion were more fatal (p<0.001). In addition, significantly more lobe involvement (mean 4.5) was observed in mortal group (p=0.009). According to the results of multivariate logistic regression analysis, 50–64 age range (p=0.028), shortness of breath (p=0.011), complaints of nauseavomiting (p=0.007), low number and percentage of eosinophils in the blood count (p=0.001), and radiological findings accompanied by pleural effusion (p=0.026) were determined as important risk factors for mortality.
Conclusion: The presence of eosinopenia and elevated CRP with lymphopenia at admission in COVID-19 patients is an indicator of poor prognosis and has been found to be associated with mortality.

Keywords: COVID-19, eosinopenia, mortality, pneumonia, prognosis.

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