AKCÝÐER TÜBERKÜLOZLU KADIN VE ERKEK OLGULARIN KARÞILAÞTIRILMASI

Bu çalýþma tüberkülozlu olgularda bakteriyolojik, radyolojik, klinik özellikler, laboratuvar bulgularý, ilaç direnç oranlarý, tedaviye yanýt ve yan etkiler yönünden kadýn ve erkekler arasýnda fark olup olmadýðýný araþtýrmak amacýyla planlandý. Kliniðimizde 4 yýllýk period içerisinde bu taný ile yatan olgularýn retrospektif olarak dosya kayýtlarý incelenerek ilk 100 kadýn (yaþ ort. 48.9) ve 100 erkek olgu (yaþ ort. 47.3.) çalýþmaya alýndý. Her iki grupta en sýk rastlanan semptom öksürük olup, balgam çýkarma dýþýnda, semptomlar açýsýndan gruplar arasýnda anlamlý farklýlýk saptanmadý. Semptomlarýn baþlama süresi kadýnlarda daha yüksek bulundu (p=0.552). Kadýnlarda tüberkülozlu ile temas (p=0.014), erkeklerde alkol ve sigara alýþkanlýðý belirgin olarak daha yüksek oranda saptandý (p=0.000). Laboratuvar deðerlerinde; anemiye kadýnlarda, hipoalbuminemiye erkeklerde anlamlý ölçüde daha yüksek oranda rastlandý. Tüberküloz ilaçlarýna karþý toplam direnç erkeklerde, daha yüksek oranda bulundu (p=0.268). En sýk görülen yan etki hepatotoksisite idi (p=0.843). Bir aylýk tedavi sonrasý radyolojik yanýt bakýmýndan gruplar arasýnda anlamlý fark saptanmadý (p=0.366). Kadýn ve erkek tüberkülozlu olgular arasýnda hastalýðýn prognozunu ya da tedavisini deðiþtirecek herhangi bir özellik saptanmamýþtýr. Tüberküloz kontrol programlarý geliþtirilmesinde cinsiyet farklýlýklarý konusuna karþý duyarlý olunmalýdýr.

COMPARISION OF THE MALE AND FEMALE CASES WITH PULMONARY TUBERCULOSIS

This study has been planned with the aim of researching the differences between male and female tuberculous cases according to bacteriological, radiological and clinical features, laboratory findings, rates of drug resistance, response to treatment and side effects of drugs. After retrospective analysis of the records of patients hospitalized in our clinic with the diagnosis of tuberculosis during a four year period, the first 100 male and 100 female cases have been included the study. While cough was the most frequent symptom in both groups, any significant difference wasn't observed among the symptoms except for sputum. The period of time for initiation of symptoms was longer in females (p=0.552). In females, the history of contact with tuberculous patient was significantly more (p=0.014), in males smoking and alcohol abuse were more (p=0.000). Among laboratory findings, anemia was more significant in females and hypoalbuminemia was more significant in males. The rate of total resistance to anti-tuberculosis agents was higher in males than in females (p=0.268). The most common side effect of treatment was hepato-toxicity and no difference was found between males and females according to the frequency of side effects (p=0.843). After a period of treatment for one month, any difference wasn't observed between the groups according to radiological response (p=0.366). Between male and female tuberculous cases, any statistically significant difference, that can alter the prognosis or treatment of tuberculosis, wasn't observed. Gender differences must be considered while developing tuberculosis control programmes.