YA� FAKT�R�N�N SARKO�DOZ HASTALI�I �ZER�NE ETK�S�

AKBABA BA�CI, Belma; B�LG�N, Sevin�; SELV�, �mm�han; YAL�INSOY, Murat; AF�AR, Bilgen Beg�m; ATIK G�NG�R, Sinem; AKKAYA, Esen

Cilt : 27 Ek : 1 Y�l : 2023

37/3Son Say� Erken Bask� Ar�iv Pop�ler Makaleler

Yazar Katk� Formu

YA� FAKT�R�N�N SARKO�DOZ HASTALI�I �ZER�NE ETK�S� [G��s Hastanesi Dergisi]

G��s Hastanesi Dergisi. 2013; 27(1): 1-11

YA� FAKT�R�N�N SARKO�DOZ HASTALI�I �ZER�NE ETK�S�

Belma AKBABA BA�CI¹, Sevin� B�LG�N², �mm�han SELV�², Murat YAL�INSOY², Bilgen Beg�m AF�AR³, Sinem ATIK G�NG�R⁴, Esen AKKAYA²
¹Kahramanmara� Necip Faz�l �ehir Devlet Hastanesi, G��s Hastal�klar�, Kahramanmara�, T�rkiye
²SB �stanbul S�reyyapa�a G��s Hastal�klar� ve G��s Cerrahisi E�itim-Arast�rma Hastanesi, G��s hastal�klar�, �stanbul, T�rkiye
³Zonguldak Uzun Mehmet G��s ve Meslek Hastal�klar� Hastanesi, G��s Hastal�klar�, Zonguldak, T�rkiye
⁴�stanbul Universal �aml�ca Hastanesi, G��s Hastal�klar�, �stanbul, T�rkiye

Sarkoidoz 20�30 ya�lar� aras�nda s�k g�r�len bir hastal�k olarak bilinmekle beraber g�n�m�zde tan� y�ntemlerinin ilerlemesi ile 50 ya� ve �zerinde de g�r�lebilmektedir. Son y�llarda 50 ya� �zeri sarkoidozlu hastalarla ilgili �al��malar dikkat �ekmektedir. Bu ama�la 1996-2005 y�llar� aras�nda merkezimizde sarkoidoz tan�s�yla takip edilen 164 hastan�n kay�tlar� retrospektif olarak incelendi. Hastalar, 50 ya� �zeri ve 49 ya� alt� olarak grupland�r�ld�. 50 ya� ve �zerinde, 61 olgu (%37) (ya� ortalamas�= 58,21 � 7,3; K/E = 5/1), 49 ya� alt�nda, 103 olgu (% 63) (ya� ortalamas� = 38,3 � 7,1; K/E= 6/4) vard�. Semptomlar kar��la�t�r�ld��nda �ks�r�k, balgam, hemoptizi, g��s a�r�s� ve nonspesifik semptom da��l�mlar� benzerdi (p>0,05). Dispne, 50 ya� �zerinde anlaml� olarak y�ksekti (p<0,01). Solunum fonksiyonlar�, dif�zyon kapasitesi, evrelerin da��l�m� ve t�berk�lin deri testi (PPD) y�n�nden gruplar aras�nda fark g�r�lmedi (p>0,05). Angiotensin d�n��t�r�c� enzim (ACE)d�zeyi 50 ya� �zerinde d��kt� (p=0,04). Ekstrapulmoner tutulumlardan periferik lenfadenopati (LAP), cilt ve g�z tutulumu benzerdi (p>0,05). Ultrasonografi ile saptanan hepatomegali ve splenomegali 50 ya� �zerinde anlaml� bulundu (p= 0,018). Sonu� olarak sarkoidoz gen� populasyona �zg� bir hastal�k de�ildir. G�n�m�zde ileri ya�ta tan� alan sarkoidozlu hastalarla ilgili �al��malar�n artmas�na ra�men, gen� grup ile kar��la�t�rmal� �al��malar hen�z yeterli say�da de�ildir. Sarkoidozun ya� gruplar�na g�re de�i�en klinik farkl�l�klar�n�n tan�mlanmas� ile bu ya� grubundaki hastalara daha kolay tan� konulaca�� kan�s�nday�z.

Anahtar Kelimeler: Sarkoidoz, ileri ya�, klinik farkl�l�klar

THE EFFECTS OF AGE FACTOR ON SARCOIDOSIS DISEASE

Although sarcoidosis is known to be common between the ages of 20-30; with the advancement of diagnostic methods can be seen in over 50 years of age. Recent studies in patients older than 50 years old with sarcoidosis are remarkable. Records of 164 sarcoidosis patients followed by us betweeen 1996-2005 were reviewed retrospectively. Patients were divided as 50 years old and over; 49 years old and under. In 50 years old and over, there were 61 paitents (%37; mean age: 58,21 � 7,3 years; F/M = 5/1) and in 49 years old and under 103 patients (%63 ; mean age: 38,3 � 7,1 years; F/M= 6/4). In comparison between the groups; cough, sputum, hemoptysis, chest pain, constitutional symptoms were similar (p>0,05). Dispnea was significantly higher in 50 years old and over (p< 0,01). No differences were seen between pulmonary function tests, diffusion capacity, sarcoidosis stage and tuberculin skin test results in two groups (p>0,05). Angiotensin converting enzyme levels were lower in 50 years old and over (p=0,04). Extrapulmonary manifestations as peripheral lymphadenopathy, skin and eye involvement were similar (p>0,05). Ultrasonographically hepatomegaly and splenomegaly were significantly higher in 50 years old and over (p = 0.018). As a result sarcoidosis is not special to young population. Despite the increase in studies on older patients with sarcoidosis, comparative studies with younger patients are not enough. We believe that as the clinical difference between different age groups are described, the diagnosis will be easier.

Keywords: Sarcoidosis, older patients, Clinical differences

Makale Dili: T�rk�e

ATIF KOPYALA

Tam Metin PDF At�f dosyas� indir RIS EndNote BibTex Medlars Procite Reference Manager Benzer makaleler PubMed Google Scholar