AKCÝÐER KANSERLÝ OLGULARDA SERUM LÝPÝD PROFÝLÝ

Çalýþmamýzda, akciðer kanser (AK)'li olgularda lipid profili deðiþikliklerini incelemeyi, histopatolojik tip ve evreyle serum lipid düzeyleri arasýndaki iliþkiyi ortaya koymayý amaçladýk. Çalýþma grubuna AK tanýsý alan, herhangi bir tedavi almamýþ 68 erkek, 28 kadýn, toplam 96 olgu, kontrol grubuna cinsiyet ve yaþça uyumlu 50 saðlýklý eriþkin alýndý. Olgularýn serum total kolesterol (KS), trigliserid (Trg), HDL, LDL ve VLDL düzeyleri ölçüldü. Serum total KS çalýþma grubunda 176,5 mg/dl, kontrol grubunda 195,8 mg/dl idi (p: 0.007). Serum LDL çalýþma grubunda 110,3 mg/dl, ve kontrol grubunda 123,1 mg/dl idi (p: 0.036). Diðer lipid düzeyleri iki grup arasýnda farklý deðildi. Akciðer kanseri histopatolojik tipleri arasýnda lipid düzeyleri farklýlýk göstermedi. Evre-III B'de total KS (p: 0.000), LDL (p: 0.000), Trg (p: 0.049) ve VLDL (p:0.029) düzeyleri kontrol grubuna göre daha düþük bulundu. Sýnýrlý evre KHAK olgular ýnda Trg (p: 0.009) ve VLDL (p:0.009) düzeyleri, yaygýn evreye göre daha düþük idi. Sigara içmeyen AK'li olgularda serum total KS (p: 0.03) ve Trg (p: 0.003) düzeyleri sigara içenlere göre belirgin þekilde düþük bulundu. Sigara kullaným süresi, metastaz yeri veya metastaz olup olmamasýna göre serum lipid düzeyleri farklýlýk göstermedi. Çalýþmamýzda; akciðer kanseri histopatolojik tipleri, sigara kullaným süresi, metastaz yeri, metastaz varlýðýna göre serum lipid düzeylerinin farklýlýk göstermediðini, Evre-III B KHDAK'li olgularda total KS, LDL, Trg ve VLDL; sýnýrlý evre KHAK'li olgularda Trg ve VLDL düzeylerinin daha düþük olduðunu tespit ettik. Akciðer kanserli olgularda taný anýnda, total KS ve LDL düzeylerini belirgin þekilde düþük bulduk. Çok basit yöntemlerle ölçülebilen serum lipidi düþük düzeylerinin akciðer kanseri þüphesi olan olgularda dikkat çekici olduðunu düþünmekteyiz.

SERUM LIPID PROFILE IN CASES WITH LUNG CANCER

In our study, we aimed to examine the lipid profile changes in cases with lung cancer (LC) and define the relationship between histopathologic types, stage and serum lipid levels. Sixty eight men and 28 women, totally 96 cases of LC and who did not have any treatment were included in the study group; and 50 healthy adults with similar sex and age were included in control group. Serum total cholesterol (CS), trigliceride (Trg), HDL, LDL and VLDL levels were measured. Serum total CS was 176,5 mg/dl in the study group and 195,8 mg/dl in control group (p: 0.007). Serum LDL was 110,3 mg/dl in the study group and 123,1 mg/dl (p: 0.036) in control group. Other lipid levels were not different between two groups. Lipid levels did not differ in histopathologic types of LC. Total CS (p: 0.000), Trg (p: 0.0049), LDL (p: 0.000) and VLDL (p: 0.029) levels in stage-III B NSCLC were significantly lower than the other stages. In limited stage SCLC, Trg (p:0.009) and VLDL (p: 0.009) levels were lower than extensive disease. In nonsmoker cases with LC; serum total CS (p: 0.03) and Trg (p: 0.003) levels were significantly lower than smokers. Serum lipid levels did not differ according to period of cigarette smoking, localization of methastases or presence of methastases. In our study; we revealed that serum lipid levels did not differ according to histopathologic types of LC, duration of smoking, and localization or presence of methastases, and total CS, LDL, Trg and VLDL levels in stage-III B NSCLC were significantly lower than other stages. In limited stage SCLC; Trg and VLDL levels were lower than extensive disease . We found significantly lower total CS and LDL levels, in the initial diagnosis period of cases with LC. We think that lower levels of serum lipids measured via very simple methods, draws attention to the cases with suspect of LC.